The sequencing of the human genome and identification of candidate genes will allow substantial innovation in the epidemiologic study of aging. Understanding genetic and environmental contributions could create novel opportunities to prevent disease and limit disability. To address this unique opportunity, the Age, Gene/Environment Susceptibility (AGES Reykjavik) Study was initiated to examine genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, a collaborative study between the National Institute on Aging, NIH and the Icelandic Heart Association.