Hertfordshire Cohort Study

DXA Measurements
DXA measurements available?: 
Yes
Type of scanner: 
Hologic
Model: 
Hologic QDR 4500
Number of LUMBAR SPINE scans in MEN: 
497
Number of LUMBAR SPINE scans in WOMEN: 
498
Number of individuals with LUMBAR SPINE BMD follow-up measurements: 
563
Number of TOTAL HIP scans in MEN: 
495
Number of TOTAL HIP scans in WOMEN: 
497
Number of individuals with TOTAL HIP BMD follow-up measurements: 
563
Number of FEMORAL NECK scans in MEN: 
495
Number of FEMORAL NECK scans in WOMEN: 
497
Number of individuals with FEMORAL NECK BMD follow-up measurements: 
563
Biochemical Bone Markers in Serum
Biochemical bone markers in serum and/or urine available?: 
Yes
Osteocalcin (OC) in serum: 
Yes
If yes, specify OC technique: 
two-site assay using using an automatic system (Elecsys, Roche Diagnostic, Manheim, Germany)
Number of OC measurements in SERUM available in individuals with DNA: 
172
Bone-specific Alkaline Phosphatase (BSALP) in SERUM: 
No
Carboxyterminal Propeptide of Type I Collagen (PICP) in SERUM: 
No
Aminoterminal Propeptide of Type I Collagen (PINP) in SERUM: 
No
Carboxy-Telopeptide of Collagen Cross-Links (CTX) in SERUM: 
Yes
If yes, specify CTX technique: 
an automated system (Serum Crosslaps, Elecsys, Roche Diagnostic, Manheim, Germany)
Number of CTX measurements in SERUM available in individuals with DNA: 
172
Amino-Telopeptide of Collagen Cross-Links (NTX) in SERUM: 
No
Cross-Linked Carboxy-Telopeptide of Type I Collagen (ICTP) in SERUM: 
No
Hip Geometry by DXA Aanalysis
Hip geometry by DXA analysis available?: 
No
Biochemical Bone Markers in Urine
Osteoprotegerin (OPG) in SERUM: 
No
Pyridinoline (PYD) in URINE: 
No
Deoxypyridinoline (DPD) in URINE: 
No
Carboxy-Telopeptide of Collagen Cross-Links (CTX) in URINE: 
Yes
If yes, specify CTX technique: 
ELISA
Number of CTX measurements in URINE available in individuals with DNA: 
176
Amino-Telopeptide of Collagen Cross-Links (NTX) in URINE: 
No
Hip Geometry by X-Ray Aanalysis
Hip geometry by X-RAY analysis available?: 
No
Other Serum Markers (Hormones and Growth factors)
Other SERUM markers (Hormones and Growth factors) available?: 
Yes
Testosterone (T) in SERUM: 
No
Estradiol (E2) in SERUM: 
No
Sex Hormone-Binding Globulin (SHBG) in SERUM: 
No
Parathyroid Hormone (PTH) in SERUM: 
No
Vitamin D (Calcidiol, 25(OH)D) in SERUM: 
Yes
If yes, specify Vitamin D (Calcidiol) technique: 
DiaSorin chemiluminescent assay
Number of Vitamin D (Calcidiol) measurements in SERUM: 
1 214
Insulin-Like Growth Factor I (IGF-I) in SERUM: 
No
Quantitative Ultrasound Measurements
Quantitative ultrasound (QUS) measurements available?: 
No
Quantitative Computed Tomography Measurements
Quantitative Computed Tomography (QCT) measurements available?: 
Yes
Type of QCT?: 
Peripheral QCT
Number of DISTAL TIBIA scans in MEN: 
295
Number of DISTAL TIBIA scans in WOMEN: 
298
Number of DISTAL RADIUS scans in MEN: 
304
Number of DISTAL RADIUS scans in WOMEN: 
316
Muscle Function Measurements
Muscle function measurements available?: 
Yes
Number of HAND GRIP STRENGTH measurements: 
2 987
Number of LEG MUSCLE STRENGTH measurements: 
381
Number of TIME TO RAISE FROM CHAIR measurements: 
971
Fall Data
Fall Data available?: 
Yes
Number of SUBJECTS with FALL DATA and DNA available: 
2 775
Number of MEN with INCIDENT FALLS: 
23
Number of WOMEN with FALLS LAST YEAR (the year before study enrollment): 
15
Number of MEN with FALLS LAST YEAR (the year before study enrollment): 
124
Number of WOMEN with FALLS LAST YEAR (the year before study enrollment): 
289
Heredity of Fractures Data
Heredity of fractures data available?: 
Yes
Number of SUBJECTS with heredity of fractures data and DNA available: 
2 979
Number of MEN with PARENTAL HIP FRACTURES: 
50
Number of WOMEN with PARENTAL HIP FRACTURES: 
46
Number of MEN with SIBLING HIP FRACTURES: 
6
Number of WOMEN with SIBLING HIP FRACTURES: 
12
History of Fracture data available?: 
Yes