Data Release 2017

The GEnetic Factors for OSteoporosis (GEFOS) Consortium is a large international collaboration comprising numerous research groups. Osteoporosis is a common age-related complex disease with a strong genetic component. Previous investigations have proved that peak bone mass is an strong determinant of osteoporotic fractures and, therefore, studies of musculoskeletal development in pediatric and adolescent populations is key to the understanding of osteoporosis etiology. Different efforts within the Consortium have and are currently focus in disentangling the genetic architecture of musculoskeletal traits. The bivariate GWAS meta-analysis of musculoskeletal traits in pediatric populations project used meta-analysis GWAS summary statistics from four different pediatric cohorts: ALSPAC, Generation R, COPSAC and BMDCS. Both Total body less head BMD (TBLH-BMD) and lean mass (TB-LM), adjusted for age, sex, height, fat mass percent and ancestry informative principal components, were meta-analyzed univariately and combined in a bivariate meta-analysis.

Release

This release comprises the summary data from our 2017 bivariate GWAS meta-analysis of musculoskeletal traits in pediatric populations. Analyses were done based on HapMap imputed data (hg18, build 36) including ~2,300,000 SNPs with MAF≥0.05 and acceptable imputation quality.

Data file description

Each file contains the following information:

CHR Chromosome BP Chromosome Position (b36) SNP RS Number EA Effect Allele OA Other Allele [Non effect allele] EAF Effect Alelle Frequency beta_BMD Beta TBLH BMD SE_BMD SE TBLH BMD P_BMD P Value TBLH-BMD beta_LM Beta TB-LM SE_LM SE TB-LM P_BMD P Value TB-LM beta_LM Beta TB-LM SE_LM SE TB-LM P_LM P TB-LM P_bivariate P Value Bivariate N Sample Size

Publications

Medina-Gomez et al. . Nature Communications 2017.

Terms of Use

We require appropriate attribution for use of data in a product, service, or publication by citing the article generating this set of results (Medina-Gomez et al, Nature 2015) and acknowledging its use.