Data Release 2017 EWAS

Data Release 2017 EWAS

A subset of the Genetic Factors for Osteoporosis (GEFOS) consortium performed an epigenome-wide association study of DNA methylation levels estimated from whole blood using the Illumina HumanMethylation450 BeadChip and DXA-derived bone mineral density measured at the femoral neck and lumbar spine.

Release

This release includes the summary data from the 2017 study of DNA methylation-based epigenome-wide association study meta-analyses. These files include summary statistics for approximately 450,000 DNA methylation probes.

Data file description

Each file contains the following information:

Illumina probe ID Effect estimate for the meta-analysis Standard error of the effect estimate for the meta-analysis Association P-value Direction of Effect in cohorts, ordered alphabetically if included in the analysis (ALSPAC, DTR, FS, RS, TUK) Heterogeneity I-squared value Heterogeneity Chi-squared statistics Heterogeneity degrees of freedom Heterogeneity P-value Probe chromosome Probe position (hg19) Annotated gene for probe

Publications

Morris JA, et al. Epigenome-wide association study of DNA methylation in whole-blood with bone mineral density. J Bone Miner Res 2017.

Terms of Use

If you are using these data, you must cite the article appropriately (Morris et al, JBMR 2017) and acknowledge its use.

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By downloading the files below, you explicitly agree to the Terms of Use stipulated above.

Files: 
2017-Morris-JBMR-EWAS.tar.gz